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  • Title: Seizures associated with high maprotiline serum concentrations.
    Author: Molnar G.
    Journal: Can J Psychiatry; 1983 Nov; 28(7):555-6. PubMed ID: 6418369.
    Abstract:
    Maprotiline is a tetracyclic antidepressant which appears to have accounted for a relatively large proportion of the seizures associated with antidepressant use. The literature proposes two mechanisms of seizure induction: interaction with other medications and concomitant medical conditions lowering the seizure threshold. Observations during a study of maprotiline blood levels suggest that elevated serum concentrations achieved with therapeutic doses may also be linked to the seizure-induction mechanism. Monitoring of maprotiline blood levels may help to identify patients at risk.
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