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  • Title: Intestinal alkaline phosphatase linked to immunoglobulin G of the kappa type.
    Author: Kohno H, Sudo K, Kanno T.
    Journal: Clin Chim Acta; 1983 Nov 30; 135(1):41-8. PubMed ID: 6418416.
    Abstract:
    An electrophoretically slow-moving alkaline phosphatase(orthophosphoric-monoester phosphohydrolase, EC 3.1.3.1, alkaline optimum, ALP) isoenzyme was found in the serum of a patient with osteomalacia. Molecular mass of this ALP was estimated to be 500 000 daltons. Inhibitor studies revealed that the abnormal ALP, which formed a macromolecular complex, was an intestinal isoenzyme. Immunofixation following electrophoresis demonstrated that the macromolecular ALP was a complex composed of intestinal ALP and immunoglobulin G of the kappa type. This isotype specificity of immunoglobulin suggested that the ALP immunoglobulin complex is a specific antigen-antibody complex in circulation.
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