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  • Title: C3 polymorphism in beta-thalassemia.
    Author: Germenis A, Kalantzi M, Karamerou A, Politi C, Fertakis A.
    Journal: Acta Haematol; 1984; 71(1):45-8. PubMed ID: 6419525.
    Abstract:
    The distribution of phenotypes and gene frequencies of the third component of complement (C3) were studied in 106 beta-thalassemic patients and in 112 carriers of the beta-thalassemia trait. A statistically significant association was found between the C3F gene and homozygous beta-thalassemia. It can be suggested that this association may be related with the high incidence of infections encountered in these patients.
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