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  • Title: Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis.
    Author: DiGiovanna JJ, Blank H.
    Journal: Arch Dermatol; 1984 Jan; 120(1):48-51. PubMed ID: 6419679.
    Abstract:
    Lysine has been claimed to be effective in the treatment and prevention of episodes of recurrent herpes simplex (HS) infection. We carried out a double-blind, placebo-controlled trial of oral lysine hydrochloride therapy (400 mg, three times a day) in a group of 21 patients in good general health with a history of frequently recurring infection. Using our measures of episode frequency, duration, and severity, we were unable to detect any substantial benefit of lysine therapy either as a treatment for episodes in progress or as a prophylactic drug for the prevention of recurrences. We conclude that it is unlikely that lysine improves frequently recurrent HS infections in the majority of patients.
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