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  • Title: The storage products in genetic and swainsonine-induced human mannosidosis.
    Author: Cenci di Bello I, Dorling P, Winchester B.
    Journal: Biochem J; 1983 Dec 01; 215(3):693-6. PubMed ID: 6419731.
    Abstract:
    Swainsonine induces the accumulation of mannose-rich oligosaccharides in human fibroblasts. The composition of the storage products shows that swainsonine completely inhibits lysosomal alpha-D-mannosidase and alters processing of glycoproteins by inhibiting Golgi alpha-D-mannosidase II. Comparison of the storage products in genetic and swainsonine-induced mannosidosis suggests that human fibroblasts contain a lysosomal alpha-D-mannosidase that is unaffected in genetic mannosidosis.
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