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  • Title: Mitomycin C intravesical therapy in noninvasive bladder cancer after failure on thiotepa.
    Author: Issell BF, Prout GR, Soloway MS, Cummings KB, Brannen G, Veenema R, Flanagan M, Block NL, Summers JL, Levin EA.
    Journal: Cancer; 1984 Mar 01; 53(5):1025-8. PubMed ID: 6420039.
    Abstract:
    Mitomycin C 40 mg in 40 ml water was administered intravesically every week for 8 consecutive weeks to 60 patients with superficial bladder cancer. All patients had failed treatment with intravesical thiotepa and had evaluable disease. An objective response of 50% or greater reduction in measured tumor mucosal involvement was obtained in 68% of patients. Forty-two percent of the patients achieved a complete response, and this included 50% of patients with Grade III disease and 70% of patients with a T1 tumor. Median response duration in complete responders was 12.2 months with a range of 3.5 to 24.3 + months. Fifty-five percent of patients are still responding. Therapy was generally well tolerated, and in contrast to thiotepa, myelosuppression was not the dose-limiting effect. One third of all patients experienced symptoms of local irritation, and skin reactions were seen in 12% of patients.
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