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  • Title: 7,12-Dimethylbenz[alpha]anthracene-DNA adducts in cultured cells from mouse fetuses of different gestational ages.
    Author: Dipple A, Pigott MA, Anderson LM.
    Journal: Cancer Lett; 1984 Jan; 21(3):285-92. PubMed ID: 6420044.
    Abstract:
    Primary cell cultures prepared from individual litters of NIH Swiss mouse fetuses of different gestational ages were incubated with 7,12-[3H]dimethylbenz[a]anthracene (DMBA) for 24 h. Levels of binding of DMBA to DNA and the distribution of individual DMBA-deoxyribonucleoside adducts were similar in all cultures derived from fetuses of 13-15 days of gestation. However, in cells from fetuses at 17-19 days changes in DMBA-DNA binding were noted. In particular the syn bay region dihydrodiol epoxide of DMBA was responsible for a significantly greater fraction of the total DMBA-DNA binding in the cultures from the more mature fetuses.
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