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  • Title: Inhibition of glycogenolysis by 2,5-anhydro-D-mannitol in isolated rat hepatocytes.
    Author: Stevens HC, Dills WL.
    Journal: FEBS Lett; 1984 Jan 09; 165(2):247-50. PubMed ID: 6420189.
    Abstract:
    2,5-Anhydro-D-mannitol, an analog of D-fructofuranose, inhibited basal and glucagon-stimulated glycogenolysis and glucose production in hepatocytes isolated from fed rats. Glucose formation from galactose was unaffected by the inhibitor. 2,5-Anhydro-D-mannitol-1-phosphate inhibits phosphorylase alpha with a Ki value of 2.4 mM. This same phosphorylated metabolite accumulates to the extent of 9.2 mumol/g wet wt in treated hepatocytes suggesting that phosphorolysis is the locus of the inhibition of glucose production from glycogen. Our results suggest that 2,5-anhydro-D-mannitol can be used to produce a model of hereditary fructose intolerance and that it merits further study as a hypoglycemic agent.
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