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  • Title: Analysis of HLA-B27 antigen with monoclonal antibodies.
    Author: Engleman EG, Calin A, Grumet FC.
    Journal: J Rheumatol Suppl; 1983 Nov; 10():59-61. PubMed ID: 6420568.
    Abstract:
    To explore the possibility that the HLA-B27 antigen may exist in more than one form, murine monoclonal antibodies were produced to B27 molecules. The first such antibody, anti-B27M1, reacts with 100% of B27 + cells and, therefore, does not distinguish B27 + healthy individuals from those with spondyloarthropathies. A second antibody, anti-B27M2, recognizes a variant of the B27 molecule that is present in most but not all Caucasian B27 + individuals. The frequency of B27M2(+) variants also appears to differ among different ethnic groups. Preliminary studies suggest that B27 + patients with ankylosing spondylitis are less likely than B27 + healthy individuals to express the B27M2 variant.
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