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  • Title: Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes.
    Author: Milam KM, Cleaver JE.
    Journal: Science; 1984 Feb 10; 223(4636):589-91. PubMed ID: 6420886.
    Abstract:
    3-Aminobenzamide and benzamide, purported to be specific inhibitors of the synthesis of poly(adenosine diphosphate-ribose), were used to elucidate possible functions of this biopolymer. These compounds, at frequently used experimental concentrations, not only inhibited the action of poly(adenosine diphosphate-ribose) synthetase but also affected cell viability, glucose metabolism, and DNA synthesis. Thus, the usefulness of 3-aminobenzamide and benzamide may be severely restricted by the difficulty of finding a dose small enough to inhibit the synthetase without producing additional metabolic effects.
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