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  • Title: The effect of polyunsaturated fatty acids on endothelial cells and their production of prostacyclin, thromboxane and platelet inhibitory activity.
    Author: Brox JH, Nordøy A.
    Journal: Thromb Haemost; 1983 Dec 30; 50(4):762-7. PubMed ID: 6420921.
    Abstract:
    Primary cultures of human endothelial cell monolayers were incubated with albumin-bound fatty acids of the omega-3 and omega-6 families for a maximum of 24 hrs, to investigate the production of 6-keto-PGF1 alpha, TXB2 and platelet inhibitory activity (PIA). Arachidonic acid was a potent stimulator of all parameters. The release of 6-keto-PGF1 alpha was significantly reduced by equimolar concentrations of linoleic, dihomogamma linolenic and eicosapentaenoic acids, but not by linolenic acid. PIA was not similarily affected. Dihomogamma linolenic acid was also a weak stimulator of 6-keto-PGF1 alpha and PIA, but reduced the content of both in the cells after 24 hrs. Eicosapentaenoic and docosahexaenoic acids both depressed 6-keto-PGF1 alpha production but PIA was maintained after 24 hrs. Indomethacin always blocked 6-keto-PGF1 alpha and PIA production. None of the effects correlated to release of 51CR from prelabelled cells.
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