These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Cellular mechanism of action of molsidomine. Bioinduction of prostacyclin].
    Author: Poincelot B, Russo-Marie F.
    Journal: Ann Cardiol Angeiol (Paris); 1983 Dec; 32(8):535-7. PubMed ID: 6421223.
    Abstract:
    Prostacyclin belongs to the family of prostaglandins, which are derived from arachidonic acid. It is secreted by vascular endothelium and possesses vasodilator and platelet anti-aggregant properties. This paper shows that molsidomine, a new anti-angina agent with vasodilator effects, is able to induce the secretion of prostacyclin by vascular endothelial cells in the aorta of the piglet. Molsidomine, via its stable metabolite SIN 1, induces very rapid and early secretion of prostacyclin followed by a refractory effect on vascular endothelium. At the same time, SIN 1 inhibits the platelet synthesis of thromboxane A2, which suggests that part of the action of molsidomine is related to an improvement in the prostacyclin/thromboxane A2 equilibrium, which has been shown to be disturbed in the course of certain cardiovascular diseases.
    [Abstract] [Full Text] [Related] [New Search]