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  • Title: The binding of polycyclic aromatic hydrocarbon diol-epoxides to DNA.
    Author: Ridler P, Jennings B.
    Journal: Cancer Lett; 1984 Feb; 22(1):95-8. PubMed ID: 6421480.
    Abstract:
    Diol-epoxide derivatives of polycyclic aromatic hydrocarbons are the ultimate carcinogenic forms of these compounds encountered in vivo. Using a novel electro-fluorescence apparatus, we report that, like the (+/-)-anti-diol-epoxide of benzo[a]pyrene (BP), the similar diol-epoxides of benzo[a]anthracene (BA) and 3-methylcholanthrene (3MC) also bind to the DNA helix at an inclination of approximately 50 degrees. This compares with the essentially perpendicular, intercalative-type binding generally found with saturated aromatic compounds, such as the native hydrocarbons, and may indicate a systematic behavior in the molecular associations precursive to carcinogenesis.
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