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  • Title: Isotype of lytic antibodies in serum of Chagas' disease patients.
    Author: Romeiro SA, Takehara HA, Mota I.
    Journal: Clin Exp Immunol; 1984 Feb; 55(2):413-8. PubMed ID: 6421519.
    Abstract:
    The isotype of anti-Trypanosoma cruzi lytic antibodies present in sera obtained from patients with the chronic phase of Chagas' disease was determined. Serum samples were submitted to gel filtration in Sephacryl S-200, ion exchange chromatography in DEAE-cellulose, affinity chromatography with protein A and immunoadsorption with anti-human IgG-Sepharose. The results of these experiments showed that human anti-T. cruzi lytic antibodies are mainly located in the IgG isotype probably in the IgG1 and IgG2 subclasses.
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