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  • Title: Arthritis in rabbits induced by killed Neisseria gonorrhoeae and gonococcal lipopolysaccharide.
    Author: Goldenberg DL, Reed JI, Rice PA.
    Journal: J Rheumatol; 1984 Feb; 11(1):3-8. PubMed ID: 6422041.
    Abstract:
    Intraarticular injections of viable N, gonorrhoeae, killed N. gonorrhoeae or gonococcal lipopolysaccharide (LPS) in rabbits' knees caused an acute, polymorphonuclear synovitis with abscess formation 24-72 h after the injection. At 5-7 days, a mononuclear infiltration with synovial lining cell hyperplasia developed, which in some rabbits persisted for one month. Gonococcal LPS, in amounts of 5 micrograms or greater, always caused a marked synovitis indistinguishable from that produced by viable N. gonorrhoeae. Gonococcal outer membrane protein used as a control in these experiments caused no or minimal synovitis in concentrations 50-fold higher than those used in the LPS inoculation experiments. These studies should provide a model to investigate the role of LPS in the arthritis associated with gonococcal infection.
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