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  • Title: HLA-ABC and DR antigens in celiac disease. A study in a pediatric Italian population.
    Author: Trabace S, Giunta A, Rosso M, Marzorati D, Cascino I, Tettamanti A, Mazzilli MC, Gandini E.
    Journal: Vox Sang; 1984; 46(2):102-6. PubMed ID: 6422636.
    Abstract:
    HLA phenotypes of 64 Italian pediatric patients with celiac disease (CD) were compared with those of a group of healthy controls. DR3 and DR7 are significantly increased as reported in other populations. In addition an increase of heterozygotes DR5/DR7 was observed in our patients. The Hardy-Weinberg distribution in the patients group shows a disequilibrium due to the genotype DR5/DR7. Our data confirm that more than one HLA gene product is associated with CD: one with DR3 and the other with DR7.
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