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  • Title: Evaluation of techniques for induction of ovulation in outpatients employing pulsatile gonadotropin releasing hormone.
    Author: Reid RL, Sauerbrei E.
    Journal: Am J Obstet Gynecol; 1984 Mar 01; 148(5):648-56. PubMed ID: 6422763.
    Abstract:
    The efficacy, safety, and patient's acceptance of intravenous and subcutaneous therapy with gonadotropin releasing hormone (GnRH) with the use of either an autoinfusion pump or a smaller manual pen pump delivery system have been evaluated during the induction of ovulation in outpatients with hypothalamic hypogonadotropic amenorrhea. An ovulatory response to intravenous GnRH was highly reproducible, even at low doses, and complications associated with the intravenous route of delivery were infrequent and readily treated. Although no complications were observed during subcutaneous GnRH therapy, the response to the subcutaneous route of delivery was unpredictable over a wide range of dosages and delivery schedules. The pen pump was rated more highly by subjects than the autoinfusion pump, because the pen pump was both light and inconspicuous.
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