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  • Title: Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes.
    Author: Serhan CN, Hamberg M, Samuelsson B.
    Journal: Biochem Biophys Res Commun; 1984 Feb 14; 118(3):943-9. PubMed ID: 6422933.
    Abstract:
    Addition of 15L-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) to human leukocytes led to the formation of a novel series of compounds containing four conjugated double bonds. The yield of tetraenes was increased approx. 100-fold when ionophore A23187 (5 microM) was added simultaneously with 15-HPETE. The structure of the major tetraene was established by physical methods as well as by chemical degradation and found to be 5,6,15L-trihydroxy-7,9,11,13-eicosatetraenoic acid.
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