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  • Title: Mammary tumor induction in analbuminemic rats by 7,12-dimethylbenz(a)anthracene.
    Author: Nagase S, Shumiya S, Tanaka H, Nagasawa H.
    Journal: Eur J Cancer Clin Oncol; 1984 Feb; 20(2):283-6. PubMed ID: 6423389.
    Abstract:
    Induction by 7,12-dimethylbenz(a)anthracene of mammary tumors was studied in analbuminemic rats, a mutant strain established from Sprague-Dawley rats which are characterized by the absence of serum albumin and hyperlipidemia. Twenty-three weeks after carcinogen administration, the incidence and average number of mammary tumors and the tumor weight per tumor-bearing rat were respectively 35.0%, 1.7 +/- 0.2 (S.E.) and 8.9 +/- 0.5 g in analbuminemic rats and 69.2%, 2.3 +/- 0.2 and 12.2 +/- 2.8 g in the controls. Associated with this lower mammary tumorigenic response, analbuminemic rats had significantly lower plasma prolactin levels than controls during proestrus at 7-8 weeks of age when carcinogen was given (176 +/- 62 vs 308 +/- 52 ng/ml).
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