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  • Title: The combined action of azlocillin and sisomicin in a model simulating the in vivo serum kinetics.
    Author: Haller I.
    Journal: Infection; 1983; 11 Suppl 2():S81-2. PubMed ID: 6423547.
    Abstract:
    The in vivo serum kinetics of azlocillin and sisomicin were simulated in a new in vitro test model. A strong synergistic effect against Pseudomonas aeruginosa resulted when both compounds were administered simultaneously and eliminated according to their individual half-life values, even when the decreasing drug concentrations exceeded the MICs for only a short period of time. When applied at intervals, neither pretreatment with azlocillin nor with sisomicin blocked the antibacterial activity of the combination partner.
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