These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Postsynaptic striatal dopamine agonist or antagonist actions of (+) or (-) 3-PPP and modification after receptor deafferentation. Author: Oberlander C, Boissier JR. Journal: J Pharmacol; 1983; 14(4):401-4. PubMed ID: 6423905. Abstract: The effects of the (+) and (-) enantiomers of 3-PPP on striatal postsynaptic dopaminergic (DAergic) receptors were studied using two rotation behaviour models in the rat. After unilateral deafferentation of the striatum by injection of 6-hydroxydopamine into the nigrostriatal DAergic tract and the development of hypersensitivity, apomorphine (0.025 mg/kg s.c.) and each of the enantiomers of 3-PPP (0.5-10 mg/kg s.c.) caused marked postural asymmetry and contralateral rotations by preferential stimulation of the DAergic receptors of the lesioned side. These rotations were antagonised by haloperidol (0.5 mg/kg i.p.). After unilateral inactivation of the nigrostriatal loop by extensive electrolytic lesion of the substantia nigra, apomorphine (0.5 mg/kg s.c.) and (+)3-PPP (25 and 50 mg/kg s.c.) caused ipsilateral rotations by stimulation of the striatal DAergic receptors on the intact side. By contrast (-)3-PPP (2-50 mg/kg i.p.) did not cause rotations and furthermore partially or completely opposed the action of apomorphine. These studies showed that (-)3-PPP has either an antagonistic or an agonistic action on the postsynaptic DAergic receptors or the striatum, respectively afferentiated or deafferentiated. Like apomorphine (+)3-PPP has a DAergic agonistic action under both circumstances.[Abstract] [Full Text] [Related] [New Search]