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  • Title: Stimulation of aflatoxin B1 and T-2 toxin production by sorbic acid.
    Author: Gareis M, Bauer J, von Montgelas A, Gedek B.
    Journal: Appl Environ Microbiol; 1984 Feb; 47(2):416-8. PubMed ID: 6424567.
    Abstract:
    Aspergillus flavus grown on yeast extract-sucrose medium produced higher amounts of aflatoxin B1 in the presence of 0.025% sorbic acid than without this chemical with a maximum at 17 days of incubation. Addition of 0.05 to 0.0125% sorbic acid stimulated T-2 toxin production of Fusarium acuminatum cultures grown on maize meal. The highest amounts of the mycotoxin were detected in 14-day-old cultures containing 0.025% sorbic acid. It is assumed that certain amounts of sorbic acid near the minimal inhibitory concentration reduce the activity of the tricarboxylic acid cycle; this may lead to an accumulation of acetyl coenzyme A, which is an essential intermediate in the biosynthesis of aflatoxin B1 and T-2 toxin.
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