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  • Title: [Effect of fat emulsion (intralipid) on essential fatty acid deficiency during total parenteral nutrition in pediatric patients. Part 1. Experimental study].
    Author: Tashiro T, Mashima Y, Okui K.
    Journal: Nihon Geka Gakkai Zasshi; 1983 Apr; 84(4):271-81. PubMed ID: 6425639.
    Abstract:
    Experimental studies were performed to confirm the effect of TPN with and without fat emulsion, Intralipid, on fat metabolism in weanling rats and puppies. Long-term fat-free TPN induced essential fatty acid (EFA) deficiency in weanling rats and the intravenous fat emulsion which accounted for 10% of the total caloric intake could prevent EFA deficiency. In the long-term TPN in growing puppies, fatfree TPN and induced EFA deficiency within two weeks, and Intralipid which accounted for 4% of the total caloric intake (2% as linoleate) satisfied the EFA requirement.
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