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  • Title: The pathogenesis of congenital hereditary lymphedema in the pig.
    Author: van der Putte SC.
    Journal: Lymphology; 1978 Mar; 11(1):10-21. PubMed ID: 642583.
    Abstract:
    The morphogenesis of congenital hereditary lymphedema was studied in pigs. The disorder, which is essentially a general underdevelopment or even total non-development of the lymphatic system proved to be present during the whole period of lymphatic development. It is suggested that a retardation in the differentiation of the lymphatic primordia from the primitive veins is the early event regulated by a chromosomal aberration. The longer this delay the more serious the lymphatic malformations.
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