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  • Title: [Preoperative immunochemotherapy for gastric cancer combined with perifocal administration of OK-432].
    Author: Mukai M, Yamazaki Y, Amano H, Hiura T, Oda S, Namiki S, Nakajima K, Nagao K.
    Journal: Gan To Kagaku Ryoho; 1984 May; 11(5):1071-7. PubMed ID: 6426402.
    Abstract:
    OMF treatment consisting of perifocal administration of OK-432 associated with MMC and 5-FU was applied for 37 lesions of 35 cases including 2 with multiple cancer. The results obtained were as follows lesions. Macroscopical efficacy was rated as "good" in 12 lesions (32.4%), "fair" in 24 lesions (64.9%) and "poor" in 1 case. Histological efficacy was assessed as "++" for 10 lesions (27%), and "+" for 16 lesions (43.2%). Taking "+" or higher histologically as "effective", the efficacy rate was approximately 71%. Efficacy rate for metastatic lymph nodes was approximately 61% in patients who underwent a curative operation. Patients who received non-curative operation showed a certain efficacy to some extent. Twenty-one cases were judged as "S2" at operation. 11 cases as "se", and another 10 cases as 2 cases of "ss beta" and 8 cases of "pm" Histologically . Seven cases of "pm" were considered either as "good" or Histological efficacy as "++" in terms of macroscopical efficacy.
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