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  • Title: [Morphologic characteristics of locus coeruleus neurons after selective chemical damage to the catecholaminergic system of the brain].
    Author: Otellin VA, Gilerovich EG, Usova IP.
    Journal: Arkh Anat Gistol Embriol; 1984 Mar; 86(3):14-22. PubMed ID: 6426440.
    Abstract:
    The initial part of the noradrenergic cerebral system--the locus caeruleus neurons--has been studied light and electron microscopically at various time after injection of 6- hydrodopamine (6-OHDA), a substance possessing a selective neurotoxic effect on the catecholaminergic mediatory system. Intracisternal injection of 6-OHDA (300 mcg) produces a number of reactive rearrangements in the neurons and large dendrites. Nevertheless, the death of the neural cells is not observed even by the 36th day.
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