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  • Title: Effect of pentoxifylline ('Trental') on cochlear blood flow as measured by hydrogen wash-out.
    Author: Maass B, Ludwig D.
    Journal: Curr Med Res Opin; 1984; 9(1):52-5. PubMed ID: 6426863.
    Abstract:
    A comparative experimental study was carried out in guinea-pigs to assess the effect of pentoxifylline on inner ear perfusion. Five animals were given a single dose of 30 mg pentoxifylline per 10-minute intravenous infusion and the cochlear blood flow measured by means of the hydrogen-clearance technique before and after administration of the drug. A control group of 11 animals received the solvent only. Compared to controls, a significant increase in inner ear blood flow was observed in the pentoxifylline-treated animals. These data may explain positive clinical findings with pentoxifylline in otological disorders associated with impaired cochlear perfusion.
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