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  • Title: Release of discrete interferons by cytotoxic T lymphocytes in response to immune and nonimmune stimuli.
    Author: Pasternack MS, Bevan MJ, Klein JR.
    Journal: J Immunol; 1984 Jul; 133(1):277-80. PubMed ID: 6427339.
    Abstract:
    We have examined the potential of murine cytotoxic T lymphocytes (CTL) to synthesize both IFN-gamma and IFN-alpha, beta by using three cloned antigen-reactive CTL lines. These lines, which produce IFN-gamma in an antigen-specific manner or after stimulation with mitogen, were also found to produce IFN-alpha, beta upon nonspecific contact with Newcastle disease virus. The requirement for viral integrity in this process has been examined. Virus infectivity was not necessary to stimulate the release of IFN-alpha, beta from CTL, but acid-inactivation of virus abrogated its IFN-inducing property.
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