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  • Title: Oral contraceptive use and the risk of breast cancer in young women.
    Author: Centers for Disease Control (CDC).
    Journal: MMWR Morb Mortal Wkly Rep; 1984 Jun 29; 33(25):353-4. PubMed ID: 6427584.
    Abstract:
    Preliminary results from the Cancer and Steroid Hormone Survey published in 1983 suggested that there is no association between oral contraceptive (OC) use and breast cancer. However, more recent studies have indicated 1) an increased risk of developing breast cancer before 25 years of age among women who use high-progestogen combination-type OCs before age 25 years, and 2) an increased risk of breast cancer before 45 years of age among women who use OCs before their 1st term birth. To evaluate these 2 findings, data from the complete 29-month file of the Cancer and Steroid Hormone Survey (CASH) were analyzed. (The results published in 1983 reflected only 10 months of data.) 1st, analysis of the relative risk of breast cancer by duration of use of high-progestogen combination OCs before age 25 years revealed no significant associations, even when women who had never used OCs were used as a reference group and the analysis was restricted to women still nulliparous at age 25 years. 2nd, the relative risk of breast cancer before age 45 years in parous women who used OCs before their 1st term pregnancy compared to those who were nonusers before the 1st term pregnancy was not elevated. It is possible that methodologic differences between the population-based Cancer and Steroid Hormone Survey and the 2 other studies account for these discrepant results.
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