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  • Title: Axoplasmic transport of norepinephrine in the locus coeruleus-hypothalamic system in the rat.
    Author: Levin BE, Stolk JM.
    Journal: Brain Res; 1977 Jan 21; 120(2):303-15. PubMed ID: 64282.
    Abstract:
    The axoplasmic transport of norepinephrine (NE) between the nucleus locus coeruleus (LC) and the hypothalamus has been measured by three methods which employ the stereotaxic injection of [3H]catecholamines in the rat brain. [3H]NE is synthesized from [3H]dopamine (DA) injected into the LC and transported at a rate of 0.8-0.9 mm/h. This rate is probably an underestimate since it includes the time required for uptake and conversion of [3H]DA to [3H]NE prior to transport. Measurement of transport of [3H]NE between the posterior and anterior hypothalamus gives a rate of 2 mm/h which is independent of [3H]DA uptake and [3H]NE synthesis. This rate is in good agreement with the 1.9 mm/h figure calculated for [3H]NE transport in the system after LC injection of [3H]NE and represents a closer estimate of the true rate of axoplasmic transport than the 0.8-0.9 mm/h estimate. Transport of [3H]NE occurs through primarily ipsilateral NE fibers running in the median forebrain bundle and is blocked by 6-hydroxydopamine lesions in the bundle. Early appearing [3H]NE in the hypothalamus forms a relatively stable pool which is unaffected by median forebrain bundle lesions and is essentially unchanged by [3H]NE transported from the LC. This pool appears to be derived from non-specific spread of [3H]DA after injection, probably through the cerebrospinal fluid.
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