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  • Title: Inhibition of jejunal water and electrolyte absorption by therapeutic doses of clindamycin in man.
    Author: Spiller RC, Higgins BE, Frost PG, Silk DB.
    Journal: Clin Sci (Lond); 1984 Jul; 67(1):117-20. PubMed ID: 6428796.
    Abstract:
    A steady-state perfusion technique has been used in vivo in normal subjects to show that at concentrations occurring during therapeutic use (500 mg/1, 1.1 mmol/l) the antibiotic clindamycin reversibly inhibits bicarbonate-stimulated water and electrolyte absorption from the human jejunum. Lactose-stimulated water and electrolyte absorption was not affected by the addition of clindamycin at the same concentration. Clindamycin-induced malabsorption of water and electrolytes may contribute significantly to the diarrhoea that occurs during clindamycin therapy in the absence of pseudomembranous colitis.
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