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  • Title: Effect of antacid on the bioavailabiity of lithium carbonate.
    Author: Goode DL, Newton DW, Ueda CT, Wilson JE, Wulf BG, Kafonek D.
    Journal: Clin Pharm; 1984; 3(3):284-7. PubMed ID: 6428800.
    Abstract:
    The effect of an antacid on the bioavailability of lithium carbonate was determined in six healthy men in a crossover study. The volunteers were given single 300-mg doses of lithium carbonate alone and with 30 ml of an antacid containing aluminum and magnesium hydroxides with simethicone. Blood samples were collected at various times for 0-24 hours after each dose. The plasma samples were analyzed for lithium using a spectrophotometer, and bioavailability variables were calculated from plasma lithium concentration-time curves. There were no significant differences in peak plasma lithium concentration, time to peak concentration, area under the concentration-time curve from 0 to 24 hours, first-order absorption rate constant, and first-order elimination rate constant between the two treatments. Concurrent administration of antacids and lithium carbonate should not affect lithium blood concentrations.
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