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  • Title: Insulin receptors in rat brain: insulin stimulates phosphorylation of its receptor beta-subunit.
    Author: Gammeltoft S, Kowalski A, Fehlmann M, van Obberghen E.
    Journal: FEBS Lett; 1984 Jun 25; 172(1):87-90. PubMed ID: 6428937.
    Abstract:
    In rat brain cortex synaptosomes insulin stimulated the phosphorylation of its own receptor beta-subunit (94 kDa) as identified by immunoprecipitation with anti-insulin or anti-receptor antiserum. The receptor alpha-subunit (115 kDa) was characterized by specific labeling with 125I-labeled photoreactive insulin. These observations indicate that: (i) insulin receptors in brain are composed of alpha-subunits which bind insulin, and beta-subunits, the phosphorylation of which can be stimulated by insulin; (ii) the size of alpha-subunits in brain is significantly smaller than in other tissues (115 vs 130 kDa), whereas beta-subunits (94 kDa) are identical. We suggest that brain insulin receptors represent a subtype regarding their binding function, whereas their enzyme function is more conserved.
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