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  • Title: Illegitimate recombination generates a class switch from C mu to C delta in an IgD-secreting plasmacytoma.
    Author: Gilliam AC, Shen A, Richards JE, Blattner FR, Mushinski JF, Tucker PW.
    Journal: Proc Natl Acad Sci U S A; 1984 Jul; 81(13):4164-8. PubMed ID: 6429663.
    Abstract:
    We present here the sequence characterization of a C mu----C delta immunoglobulin (Ig) heavy chain class switch. In the murine IgD-secreting plasmacytoma TEPC 1017, deletion of most of the mu switch recombination region (S mu) and the entire C mu gene occurred in the absence of switch region sequences 5' to C delta. This unique rearrangement resulted from an illegitimate recombination of sequences with only patchy homology to each other. The infrequent and variable nature of illegitimate recombination may explain the low frequency of IgD-secreting plasma cells in normal mouse tissues.
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