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  • Title: Factor VIII inhibitor treatment with high doses of F VIII.
    Author: Stenbjerg S, Ingerslev J, Zachariae E.
    Journal: Thromb Res; 1984 Jun 15; 34(6):533-9. PubMed ID: 6429891.
    Abstract:
    A hemophilic patient with F VIII inhibitor was treated with intermittent F VIII infusions of 40 - 50 units per kg bodyweight per week. Although the inhibitor declined during treatment, an anamnestic response was recorded on two occasions. A continuous high dose F VIII regimen of 200 units per kg per day resulted in reduction of the inhibitor concentration to less than 1 unit per ml. No anamnestic response was seen after a later exposure to intensive F VIII therapy.
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