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  • Title: Differential diagnosis between hypothalamic and pituitary hGH deficiency with the aid of synthetic GH-RH 1-44.
    Author: Laron Z, Keret R, Bauman B, Pertzelan A, Ben-Zeev Z, Olsen DB, Comaru-Schally AM, Schally AV.
    Journal: Clin Endocrinol (Oxf); 1984 Jul; 21(1):9-12. PubMed ID: 6430606.
    Abstract:
    Synthetic GH-RH 1-44 administered as an intravenous bolus (1 microgram/kg) evoked a marked hGH rise (greater than 20 ng/ml) in three children with constitutional short stature and in two of eight children diagnosed as having hGH deficiency by insulin hypoglycaemia and/or clonidine tests. As judged by the intensity of the hGH response to the dose employed and the peak time, GH-RH 1-44 may be as potent as GH-RH 1-40 in children. It is concluded that GH-RH is an important addition to the endocrine armamentarium, providing the means for differentiation between hypothalamic and pituitary hGH deficiency in a simple test which is devoid of side effects.
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