These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Emergence of Streptococcus faecalis isolates with high-level resistance to multiple aminocyclitol aminoglycosides.
    Author: Ikeda DP, Barry AL, Andersen SG.
    Journal: Diagn Microbiol Infect Dis; 1984 Jun; 2(3):171-7. PubMed ID: 6430629.
    Abstract:
    Isolates of Streptococcus faecalis were occasionally found to be resistant to gentamicin concentrations of 500 micrograms/ml in a microdilution tray. Additional tests were performed with 28 such isolates. They all demonstrated high-level resistance (minimum inhibitory concentration greater than 2000 micrograms/ml) to gentamicin, kanamycin, sisomicin, streptomycin, and tobramycin. This high-level aminoglycoside resistance was associated with total resistance to in vitro synergism when each aminoglycoside was combined with ampicillin. In addition to ampicillin-aminoglycoside combinations, ampicillin-vancomycin, ampicillin-rifampin, rifampin-vancomycin, and vancomycin-gentamicin combinations were also tested; all failed to exhibit an in vitro synergistic-bactericidal effect against these enterococci. The emergence of enterococci with high-level resistance to multiple aminoglycosides in this clinical population is a source of grave concern with obvious therapeutic implications in situations such as endocarditis, where an in vitro bactericidal effect is thought to be necessary for a cure. No drug or combination of drugs was found to be bactericidal for these isolates. It is suspected that similar isolates of group D streptococci with high-level resistance to gentamicin may emerge in other institutions but go unrecognized. Surveillance by others for identifying this newly emerging pathogen carrying multiple resistance and a continued search for a satisfactory chemotherapeutic agent(s) are encouraged.
    [Abstract] [Full Text] [Related] [New Search]