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  • Title: Mitomycin C induced chromosome damage in fetal blood cultures and prenatal diagnosis of Fanconi's anaemia.
    Author: Shipley J, Rodeck CH, Garrett C, Galbraith J, Giannelli F.
    Journal: Prenat Diagn; 1984; 4(3):217-21. PubMed ID: 6431403.
    Abstract:
    We report the use of fetal blood for the prenatal diagnosis of Fanconi anaemia (FA). The clastogenic action of Mitomycin C (MMC) is compared in blood cultures from different fetuses, normal controls and FA heterozygotes. The fetus at risk is shown to suffer from FA on the grounds of excessive chromosome breakage, both spontaneous and MMC induced.
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