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  • Title: Rapid proteolysis of puromycyl peptides in non-thalassaemic and thalassaemic erythroid cells.
    Author: Chalevelakis G, Lyberatos C, Yalouris A, Vaidakis E, Pallikaris G, Raptis S.
    Journal: Eur J Clin Invest; 1984 Jun; 14(3):199-202. PubMed ID: 6432547.
    Abstract:
    The proteolytic degradation of labelled pyromycyl polypeptides was investigated in human intact erythroid cells derived from the bone marrow of eight non-thalassaemic patients and the peripheral blood of eleven thalassaemics (eight splenectomized beta thalassaemia heterozygotes and three sickle-cell beta thalassaemics). These abnormal polypeptides are rapidly degraded to soluble trichloroacetic-acid (TCA) fragments with a half-life of 12 min both in bone marrow and peripheral blood. This comes very close to the half-life reported for the puromycyl peptide degradative system in rabbit reticulocytes (15 min). The relationship of the present proteolytic system to the ATP-dependent one, described in rabbit reticulocytes, and to that responsible for the free alpha-chain degradation in beta thalassaemia is discussed.
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