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  • Title: Ornithine uptake by isolated hepatocytes and distribution within the cell.
    Author: Zollner H.
    Journal: Int J Biochem; 1984; 16(6):681-5. PubMed ID: 6432597.
    Abstract:
    Uptake of ornithine by isolated hepatocytes and its distribution within the cell was investigated. Ornithine uptake was energy independent and exhibited a saturable and a nonsaturable component. The Km value of the saturable component was 1.3 mM. At an external ornithine concentration of 0.5 mM the rate of ornithine uptake was 127 +/- 19 nmol/g. Lysine inhibited ornithine uptake, indicating the existence of an ornithine transport system. It was concluded that ornithine transport can limit urea synthesis in the state of transition from a low ammonia to a high ammonia supply.
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