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  • Title: Magnesium and the regulation of germ-tube formation in Candida albicans.
    Author: Walker GM, Sullivan PA, Shepherd MG.
    Journal: J Gen Microbiol; 1984 Aug; 130(8):1941-5. PubMed ID: 6432954.
    Abstract:
    Candida albicans requires Mg2+ for germ-tube formation. Mg-deficient media, metal ion chelators and the ionophore A23187 inhibited germ-tube formation. Cell Mg content during exponential yeast-phase growth remained constant but increased throughout germ-tube formation. The onset of germ-tube formation coincided with a sharp peak in Mg concentration within the cells. Yeast-phase cells of strain CA2, which did not form germ-tubes, had a lower Mg content and failed to accumulate Mg when incubated under conditions for germ-tube formation. Mg also increased the uptake and incorporation of N-acetylglucosamine. These findings point to a central regulatory role for Mg in C. albicans morphogenesis.
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