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  • Title: The human apolipoprotein A-II gene is located on chromosome 1.
    Author: Lackner KJ, Law SW, Brewer HB, Sakaguchi AY, Naylor SL.
    Journal: Biochem Biophys Res Commun; 1984 Aug 16; 122(3):877-83. PubMed ID: 6433912.
    Abstract:
    Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21----qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosomes 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.
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