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  • Title: Essential arginine residues for catalytic and regulatory functions of alpha-ketoglutarate dehydrogenase from pigeon breast muscle.
    Author: Stafeeva OA, Gomazkova VS, Severin SE.
    Journal: Biochem Int; 1983 Mar; 6(3):315-21. PubMed ID: 6433927.
    Abstract:
    The number of arginine residues of pigeon breast muscle alpha-ketoglutarate dehydrogenase modified by 2,3-butanedione and 2,4-pentanedione was determined. It was shown that two of the 40 arginine residues in the enzyme monomer (Mr = 86,000) are accessible to the action of dicarbonyl compounds and are functionally significant. The protective effect of alpha-ketoglutarate and ADP against enzyme modification by 2,3-butanedione suggests the participation of alpha-ketoglutarate dehydrogenase arginine residues in the binding of substrate and allosteric activator, ADP.
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