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  • Title: The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide.
    Author: File SE, Pellow S.
    Journal: Brain Res; 1984 Sep 17; 310(1):154-6. PubMed ID: 6434155.
    Abstract:
    The benzodiazepine receptor antagonist, Ro 15-1788 (10 mg/kg) is anxiogenic in the social interaction test. Acute administration of chlordiazepoxide (5 or 10 mg/kg) did not reverse the anxiogenic effects of Ro 15-1788; however, in animals pretreated with chlordiazepoxide (5 mg/kg) for 5 days prior to testing, there was a reduction in the anxiety produced by Ro 15-1788.
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