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  • Title: Vasoactive drugs and elastic properties of human arteries in vivo, with special reference to the action of nitroglycerine.
    Author: Westling H, Jansson L, Jonson B, Nilsén R.
    Journal: Eur Heart J; 1984 Aug; 5(8):609-16. PubMed ID: 6434312.
    Abstract:
    Pulsatile changes in the volume of an arm segment were recorded with an air-filled plethysmograph and related to intra-arterial blood pressure. Alterations in transmural arterial pressure were obtained by changing the pressure in a large chamber surrounding the entire arm. Arterial compliance values were calculated in late diastole when pressure and volume changes were slow. Compliance varied with transmural arterial pressure in a hyperbolic manner, rising steeply at low pressure. Noradrenaline and hypertensin did not change the arterial compliance values, while dihydroergotamine reduced them. Nitroglycerine caused a pronounced increase in compliance values in doses that did not change cardiac output and arterial pressure.
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