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  • Title: [Role of sympathetic nervous system in the pathogenesis of spontaneous hypertension in rats].
    Author: Rodionov IM, Markov KhM, Pinelis VG, Kozlov AV, Koshelev VB.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1984 Jun; 70(6):789-94. PubMed ID: 6434353.
    Abstract:
    The structural component of resistance and vascular reactivity in posterior half of the rat body were studied in intact normotensive animals as well as in rats with hereditary hypertension. Chemical desympathization in the spontaneously hypertensive rats reduced the arterial pressure, cardiac outflow, structural component of the resistance and reactivity to noradrenaline, these parameters remaining, however, higher than in normal intact rats. 2-week hypoxic adaptation of young spontaneously hypertensive rats hinders increasing of the arterial pressure and structural component of resistance. The augmented sympathetic activity along with other factors (genetic, humoral) seem to increase the structural component of resistance and arterial pressure in spontaneously hypertensive rats.
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