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  • Title: Blockade of hp-GRF-40-induced GH release in normal men by a cholinergic muscarinic antagonist.
    Author: Massara F, Ghigo E, Goffi S, Molinatti GM, Müller EE, Camanni F.
    Journal: J Clin Endocrinol Metab; 1984 Nov; 59(5):1025-6. PubMed ID: 6434584.
    Abstract:
    In five healthy young men, pretreatment with the cholinergic muscarinic antagonist pirenzepine (0.6 mg/kg iv) almost completely abolished the rise in plasma growth hormone (GH) elicited by an iv bolus injection of 1 microgram/kg human pancreatic GH-releasing factor 1-40 (hp-GRF-40). These data demonstrate that cholinergic receptor sites involved in GH-releasing mechanisms do not interact with GRF-secreting structures in the central nervous system. A mechanism mediated via hypothalamic release of somatostatin or, alternatively, a direct pituitary site of action, can be postulated for the blocking effect of pirenzepine.
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