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  • Title: Immunoglobulin light chains in chronic lymphocytic leukemia and related diseases.
    Author: Hirsch FW, Wagner M, Bross KJ, Guttkowski K, Dölken G, Löhr GW.
    Journal: Blut; 1984 Oct; 49(4):339-45. PubMed ID: 6435702.
    Abstract:
    The combination of two-dimensional mini gel electrophoresis with the 'western blot' technique proves to be a powerful tool in characterizing lymphoid cells. By testing for kappa and lambda immunoglobulin light chains we were able to differentiate between mono-, oligo-, and polyclonal B-cell diseases. The distribution of the lambda isotypes of 24 cases with chronic lymphocytic B-cell leukemia (B-CLL) tested was not random when compared to the distribution of the lambda light chains in B-lymphocytes of normal persons. This might implicate a genetic link between the lambda loci (chromosome 22) and the development of the lambda-CLL.
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