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  • Title: Evidence for the occurrence of a fast-acting inhibitor for tissue-type plasminogen activator in human plasma.
    Author: Verheijen JH, Chang GT, Kluft C.
    Journal: Thromb Haemost; 1984 Jul 29; 51(3):392-5. PubMed ID: 6437006.
    Abstract:
    Human plasma contains a fast-acting t-PA inhibitor, which is not identical with alpha 2-antiplasmin or alpha 2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurring plasma concentrations of t-PA (0-2 IU/ml). The inhibitor binds to concanavalin A-Sepharose, is rather stable when heated, is not precipitated in euglobulin fractions and probably does not originate from platelets. The inhibitor seems to form a 190 Kd complex with t-PA. The relation between this plasma inhibitor and the recently discovered endothelial cell inhibitor is not yet clear.
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