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  • Title: Inhibitor to factor VIII in mild haemophilia.
    Author: Kesteven PJ, Holland LJ, Lawrie AS, Savidge GF.
    Journal: Thromb Haemost; 1984 Aug 31; 52(1):50-2. PubMed ID: 6437010.
    Abstract:
    Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for symptomatic management. When inhibitor titres were low, endogenous F VIII stimulation, by DDAVP, was less immunogenic than the administration of exogenous F VIII concentrates. This inhibitor displayed characteristics of an autoantibody, and was characterised as an immunoglobulin of IgG subtype.
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